username password Remember Me Lost Password Lost Username Create Account
Home Articles||Healthy Articles Pharmacology Therapeutic Concentration
Therapeutic Concentration PDF Print E-mail
Written by dr rend-san   
Thursday, 04 February 2010 07:06

For many drug  there is a range of plasma concentrations that is associated with a clinical improvement in the majority of patients. Plasma concentration of drugs are described as subtherapeutic and toxic, respectively. Plasma concentration in the high therapeutic range may be considered potentially toxic.

The therapeutic plasma concentration is not a marginal range that guarantees successful treatment without adverse effect. Some patient require only a low plasma concentration, presumably because of differences in disease severity, tissue sensitivity, or pathophysiology. A low therapeutic or even subtherapeutic concentration may be adequate for their management. This level usually cannot be predicted in advance.

Adverse reaction may occur within the so called therapeutic concentration range. They may represent normal biological variation, enhanced sensitivity, idiosyncrasy, altered body binding, or variation in the “milieu interieure”, which may be superficially characterized by electrolyte disturbance. There may be summation or synergy with other medications. The measurement of drug concentration may be inaccurate, or the sample may be taken at an inappropriate time. The methodology may be disturbed, for example, by hemolysis, bile pigmentation, and the presence of other drug or interfering metabolites. Laboratory errors, both human and mechanical, may also occur.

When dosage or plasma concentration and response are not compatible by normal standards, pharmacodynamic, pharmacokinetic, or analytical interference should be considered. Many important interactions between drugs and disease have been exposed in this way.  (doc r3nd5an)

Last Updated on Thursday, 04 February 2010 07:09
 

Add comment


Security code
Refresh

Featured Article

Chemical Injuries Of Ocular

article thumbnail

Chemical injuries of ocular are included in the most urgent of ocular emergencies. Bad effect severity depends on the solution pH, time of contact, quantity of solution, and ability to penetrate into  [ ... ]


Latest Comments

Who's Online

We have 57 guests online

Healthy Syndicate

feed-image Healthy Feed Entries