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By HC-Team
08 Mar 2010

Protein Binding and Volume of Distribution

The unbound fraction of several acidic drugs may be increased in uremia, even when the concentration of the serum albumin is normal. The reduction in binding of phenytoin is related to the decrease in renal function ( 20% unbound drug at a serum creatinine level of 10-12 mg/dl compared to about 10% unbound with normal renal function). One practical implication of this information is that the uremic patient whose total plasma phenytoin level is below the therapeutic range may still have adequate seizure control because the unbound concentration is in the middle or high usual therapeutic range. If necessary, total and unbound plasma concentrations should be measured.

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By HC-Team
08 Mar 2010

Incorrect Prescribing

If the diagnosis is wrong, incorrect prescribing will occur. It also occurs when a physician is forget and not aware that genetic and environtmental factors or the disease per se may alter the patient's response to a drug. For example; (1) Cigarette-smoking may markedly accelarate the rate elimination of a variety of drugs, (2) Patients with the nephrothc syndrom have low plasma albumin concentrations. These condition are associated with an increased fraction of unbound clofibrate and phenytoin, but the steady state concentration of the unbound drug is not altered because of compensatory changes

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By HC-Team
07 Mar 2010

LASIK Eye Surgery

LASIK is an elected laser eye surgery that reshapes the beguiler rise of the eye (the cornea) to meliorate sensation. It is the most touristed sensation redaction surgery performed in the Unsegmented States and worldwide.

LASIK can reverse a sweeping extent of ametropia (ametropia), farsightedness (hyperopia) and ametropia. Variations and enhanced versions of LASIK countenance all-laser LASIK, trade LASIK (also called surface LASIK or wavefront-guided LASIK) and multifocal LASIK.

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By Fallen
06 Mar 2010

The Improvement to Reduce the Radiation Effect

One machine that is really important in medical field is CT scanner. CT scanners are machines that give three-dimensional pictures that give an almost surgical view of the body. This procedure is conducted to evaluate trauma, seizures, belly pain, chronic headache, and so on. The development in technology is attempting to manufacture CT scanners that give less radiation. FDA stated that the radiation produced by one CT scanner as nearly 400 chest X-rays. Good news come to the horizon is that medical imaging trade group announced that CT scanners manufacturers will start installing safety controls to prevent of excessive radiation. It would help patients by reducing the radiation they receive.

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By Fallen
05 Mar 2010

When People Start Worry Taking Avandia

Many sources have officially reported the effect of consuming Avandia. In 2007, New England Journal of Medicine reported the serious effects of consuming this type 2 diabetes drugs. The study concluded that Avandia potentially cause cardiac effects. Therefore, this announcement has pulled reactions from public especially those who are consuming Avandia. Of course the drug manufacturer, GlaxoSmithKline objected the report.

Starting from 2007 to 2009, some documents delivered similar reports which were announced stating that Avandia may cause some serious risks of health problem. It is found out that people who taking Avandia will have higher risk of heart attack or probably death from cardiovascular causes. Furthermore, compare to the diabetes drug in the same class, Actos, older patients with diabetes taking Avandia have more risks for getting heart attack or death.

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Chemical Injuries Of Ocular

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Chemical injuries of ocular are included in the most urgent of ocular emergencies. Bad effect severity depends on the solution pH, time of contact, quantity of solution, and ability to penetrate into  [ ... ]


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